• Spectrum Chromatograph
  • Dissolved O2, O3, H2 analyzer
  • Sonic densitometer
  • Dissolved carbon dioxide analy
  • Other instrumentation
  • STILL

    STILL  


    Principle

    According to pharmaceutical standards and by definition, water for injection (WFI) is water required for manufacturing medicines for parenteral administration. The Centec multi effect distillation system STILL is designed for the production of sterile, pyrogen-free WFI. The unit consists of a series of interconnected columns. Pre-treated feedwater enters into the first column. Using external energy, a significant proportion of it evaporates in the first tubular heat exchanger. In order to separate any water droplets that might harbour contaminants like particles and pyrogens, the column contains an expansion chamber. While the steam moves further upwards in the chamber, the water droplets fall into its lower section by gravity, thus separating from the steam. The non-evaporated water flows into the next column, where it is again heated in a heat exchanger using steam produced in the previous stage. While another portion of the water evaporates, some steam condenses into WFI. This process is repeated in each column. To condense the steam produced in the final column, cooling water is used. The WFI is at 80 °C and needs to be kept at this temperature to prevent the growth of microorganisms.


    Characteristic

    ·Application Specific and Energy Efficient optimized gravitational separation method WFI storage and loop on demand 

    · Modular Design with Standard PLC skid mounted for easy installation and start-up 

    · In Compliance with USP, ASME, GMP, FDA, ISPE 

    · Completely Qualified (DQ, IQ, OQ) 

    · Low Operating and Maintenance Costs

     

    Technical Data 

    Capacity                                                                  0 - 20 m3/h

    Number of Columns                                            Up to 8

    WFI Temperature                                                  80 °C (lower on request)

    Total Bacteria                                                         < 10 CFU/100ml

    Endotoxin                                                                < 0.25 EU/ml 

    Residual Conductivity                                          < 1.1 mS/cm (20°C)

    Material                                                                    1.4404/1.4435/… AISI 316L/… electropolishing possible

    Surface Finish                                                         Ra < 0,4 possible

    Ferrite Content                                                        < 1 % possible

    PLC                                                                             SIMATIC S7

    Options                                                                      Water pre-treatment WFI storage & distribution 


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